Crossword clue

“Infection-fighting immune system component”

This clue appeared as 50-Down in the USA Today Crossword on Friday, August 21, 2026. The answer has 5 letters.

Answer · 5 lettersFirst appearance
TCELL
Letters5
Starts withT
Ends withL
Vowels1

Where this clue has appeared

USA Today Crossword
Aug 21, 20265 letters→

About this clue

The clue “Infection-fighting immune system component” ran in the USA Today Crossword on August 21, 2026 as 50-Down. Its answer is a 5-letter word that starts with T and ends with L, with only 1 vowel, so think abbreviations or consonant clusters.

See every answer from the puzzle on the USA Today Crossword page for August 21, 2026, or learn how clues like this work in our guide to crossword clue types.

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FAQ

What is the answer to the “Infection-fighting immune system component” clue?+

The answer is TCELL (5 letters), from the USA Today Crossword of August 21, 2026.

Where has this clue appeared?+

We have seen it 1 time in the USA Today Crossword.

How do I find other USA Today Crossword answers?+

Open the full list of answers for August 21, 2026, or browse every date on the USA Today Crossword hub.