What is the answer to the NYT Crossword clue "Esoteric knowledge" from September 21, 2025?

Crossword clue

“Esoteric knowledge”

This clue appeared as 49-Down in the NYT Crossword on Sunday, September 21, 2025. The answer has 6 letters.

Answer · 6 lettersFirst appearance

ARCANA

Letters6

Starts withA

Ends withA

Vowels3

Where this clue has appeared

NYT Crossword
Sep 21, 20256 letters→

About this clue

The clue “Esoteric knowledge” ran in the NYT Crossword on September 21, 2025 as 49-Down. Its answer is a 6-letter word that starts with A and ends with A, with 3 vowels, which often points to a phrase, a name or a borrowed word.

See every answer from the puzzle on the NYT Crossword page for September 21, 2025, or learn how clues like this work in our guide to crossword clue types.

More clues from this puzzle

1AVineyard measure4 letters 5ADoes acid5 letters 10ATree with doubly serrated leaves3 letters 13A[Hey!]4 letters 17ALocations in the game Clue5 letters 19AGrand duke of Luxembourg beginning in 20005 letters 20AHeart of the matter4 letters 22APalindromic Italian number4 letters

FAQ

What is the answer to the “Esoteric knowledge” clue?+

The answer is ARCANA (6 letters), from the NYT Crossword of September 21, 2025.

Where has this clue appeared?+

We have seen it 1 time in the NYT Crossword.

How do I find other NYT Crossword answers?+

Open the full list of answers for September 21, 2025, or browse every date on the NYT Crossword hub.